Table 2.
The overlapping genes and single nucleotide polymorphisms with bipolar disorder and dementia.
| Diagnosis | SNPs | Position | Minor Alleles | Allele Directions | Author |
|---|---|---|---|---|---|
| Gene: CACNA1C | |||||
| Bipolar disorder | rs1006737 | chr12:2236129 | A | + | Chen et al., 2013 (27); Ferreira et al., 2008 (35); Green et al., 2013 (28) |
| Bipolar disorder | rs1024582 | chr12:2293080 | A | + | Ferreira et al., 2008 (35) |
| Bipolar disorder | rs10744560 | chr12:2277933 | T | + | Stahl et al., 2019 (19) |
| Bipolar disorder | rs10848642 | chr12:2222406 | G | – | Chen et al., 2013 (27) |
| Bipolar disorder | rs11062170 | chr12:2239678 | C | + | Mullins et al., 2021 (14) |
| Bipolar disorder | rs4765913 | chr12:2310730 | A | + | Green et al., 2013 (28); Psychiatric GWAS Consortium Bipolar Disorder Working Group, 2011 (31) |
| Vascular dementia | rs11062164 | chr12:2224486 | A | + | Schrijvers et al., 2012 (50) |
| Gene: GABBR2 | |||||
| Bipolar disorder | rs7864144 | chr9:98643756 | G | – | Xu et al., 2014 (26) |
| Vascular dementia | rs16916777 | chr9:98518893 | A | + | Schrijvers et al., 2012 (50) |
| Gene: SCN2A | |||||
| Bipolar disorder | rs17183814 | chr2:165295879 | G | + | Mullins et al., 2021 (14); Stahl et al., 2019 (19) |
| Late-onset Alzheimer’s disease | rs10184275 | chr2:165271418 | – | – | Beecham et al., 2009 (48) |
| Late-onset Alzheimer’s disease | rs2119067 | chr2:165270773 | – | – | Beecham et al., 2009 (48) |
| Gene: CTSH | |||||
| Bipolar disorder | rs16970287 | chr15:78935915 | G | + | Yosifova et al., 2011 (32) |
| Bipolar disorder | rs2289700 | chr15:78932341 | A | + | Yosifova et al., 2011 (32) |
| Alzheimer’s disease | rs12592898 | chr15:78936857 | A | – | Bellenguez et al., 2022 (15) |
| Gene: MSRA | |||||
| Bipolar disorder | rs3088186 | chr8:10368845 | T | + | Mullins et al., 2021 (14) |
| Alzheimer’s disease | rs4607615 | chr8:10422116 | C | – | Sherva et al., 2023 (37) |
| Gene: SH3PXD2A | |||||
| Bipolar disorder | rs2281587 | chr10:103617592 | C | + | Psychiatric GWAS Consortium Bipolar Disorder Working Group, 2011 (31) |
| Vascular dementia | rs17738042 | chr10:103596274 | A | + | Schrijvers et al., 2012 (50) |
CACNA1C, Calcium voltage-gated channel subunit Alpha1 C; CTSH, Cathepsin H; GABBR2, Gamma-aminobutyric acid B receptor 2; GWAS, Genome-wide association studies; MSRA, Methionine sulfoxide reductase A; SH3PXD2A, SH3 and PX domains 2A; SNPs, Single nucleotide polymorphisms; SCN2A ,Sodium voltage-gated channel Alpha subunit 2.