Table 2.

Multivariate logistic regression for analyzing the lung metastasis-associated factors in the training cohort (n = 910).

Variables	Training cohort (N = 910)
	OR (95% CI)	P
Age(years)
<18	1 (reference)
18–50	0.936 (0.358–2.547)	0.894
>50	1.010 (0.562–1.826)	0.972
Race
White	1 (reference)
Black	0.678 (0.233–1.872)	0.460
Other	0.783 (0.397–1.626)	0.495
Year of birth
<1970	1 (reference)
1970–2000	0.516 (0.126–2.005)	0.346
>2000	0.754 (0.322–1.849)	0.526
Grade
Grade I	1 (reference)
Grade II	0.416 (0.021–2.892)	0.438
Grade III	4.231 (1.422–15.664)	0.016*
Grade IV	5.151 (1.732–19.170)	0.006*
Unknown	4.599 (1.583–16.839)	0.010*
ICD O 3 Histologic type
Osteosarcoma	1 (reference)
Chondrosarcoma	1.647 (0.748–3.716)	0.221
Ewing Sarcoma	0.222 (0.067–0.639)	0.008*
Chordoma	1.587 (0.831–3.111)	0.168
Origin laterality
Left	1 (reference)
Right	1.346 (0.816–2.235)	0.246
Other	0.667 (0.390–1.139)	0.138
Tumor size (cm)
<5.0	1 (reference)
5.0–10.0	1.447 (0.680–3.377)	0.361
>10.0	2.182 (1.045–5.022)	0.049*
Tumor extension
Inside periosteum	1 (reference)
Beyond periosteum	0.445 (0.244–0.771)	0.006*
Lymph node involvement
No	1 (reference)
Yes	1.869 (1.046–3.264)	0.031*
Other site metastasis
No	1 (reference)
Yes	2.316 (1.430–3.729)	0.001*
Insurance
Insured	1 (reference)
Medicaid	1.479 (0.841–2.557)	0.166
Other	0.722 (0.415–1.218)	0.233
Marriage
Married	1 (reference)
Divorced	2.373 (0.628–15.797)	0.988
Single	2.845 (0.698–19.702)	0.199
Widowed	1.462 (0.206–12.783)	0.705
Other	3.294 (0.520–27.928)	0.220

Multivariable logistic regression: (*) at a p-value <0.05.

Grade I, well differentiated; Grade II, moderately differentiated; Grade III, poorly differentiated; Grade IV, undifferentiated.