Figure 1.

The transition of M1 to M2 phenotype in normal wound and diabetic wound. Compared to normal wound, macrophage polarization is dysregulated in the diabetic wound, which hinders the transition of the diabetic wound healing process from the inflammatory phase to the proliferative phase. During the inflammatory phase, the levels of M1 and M2 macrophages are significantly reduced in diabetic wound. During the proliferative phase, the population of M1 macrophages in diabetic wounds is considerably higher than that in normal wounds, while M2 macrophages remain at a relatively low level. This figure was created with the aid of Biorender (https://biorender.com/).