Figure 5.

Pharmacological modulators targeting histone modification enzymes to influence macrophage phenotype. During the normal wound healing process, the phenotype of macrophages gradually shifts from pro-inflammatory M1 phenotype to anti-inflammatory M2 phenotype. In the process of wound healing in diabetes, macrophages persist in the M1 phenotype, but will not change into the M2 anti-inflammatory phenotype, which is considered to result in dysregulated angiogenesis, chronic inflammation and impaired tissue repair. The regulatory enzymes involved in histone modifications affecting macrophage phenotype may provide a new therapeutic strategy for wound healing. This figure was created with the aid of Biorender (https://biorender.com/).