Table 2.
Mendelian randomized estimation of the association between micronutrients and autoimmune thyroiditis.
| Exposure | Outcome | IVW | MR-Egger | Weighted median | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| OR (95% CI) | P-value | Cochran Q | P-value | OR (95% CI) | P-value | MR-Egger intercept | P-value | OR (95% CI) | P-value | ||
| Copper | Autoimmune thyroiditis | 0.918 (0.315-2.674) | 0.875 | 3.069 | 0.080 | NA | NA | NA | NA | NA | NA |
| Iron | Autoimmune thyroiditis | 0.653 (0.309-1.379) | 0.264 | 0.756 | 0.683 | 1.009 (0.218-4.676) | 0.993 | -0.086 | 0.639 | 1.639 (0.288-1.415) | 0.269 |
| Calcium | Autoimmune thyroiditis | 0.964 (0.523-1.776) | 0.906 | 216.124 | 0.132 | 1.310 (0.436-3.935) | 0.631 | -0.010 | 0.512 | 1.342 (0.435-4.139) | 0.609 |
| Vitamin D | Autoimmune thyroiditis | 0.717 (0.341-1.504) | 0.378 | 90.420 | 0.949 | 1.951 (0.623-6.111) | 0.254 | -0.037 | 0.026 | 1.265 (0.398-4.026) | 0.690 |
| Vitamin C | Autoimmune thyroiditis | 0.986 (0.828-1.175) | 0.875 | 76.166 | 0.142 | 0.847 (0.549-1.306) | 0.455 | 0.089 | 0.454 | 0.845 (0.645-1.108) | 0.223 |
| Zinc | Autoimmune thyroiditis | 0.789 (0.370-1.682) | 0.539 | 1.479 | 0.224 | NA | NA | NA | NA | NA | NA |
NA, Insufficient number of SNPs for analysis.