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. 2024 Jul 12;131(5):860–869. doi: 10.1038/s41416-024-02721-8

Fig. 3. Therapeutic impact of WGS in sarcoma (case 31).

Fig. 3

a Circos plot of WGS showing strong mutational burden of indel variants (green track). b Signature breakdown showing strong mismatch repair signature. c CT scan images of a 56-year-old male with progressive lung and pelvic metastases from UPS following two previous lines of chemotherapy showing excellent partial response to the immune checkpoint inhibitor pembrolizumab.