Table 3.
Sensitivity analyses: HR and 95% CI (Q4 vs. Q1) for incident type 2 diabetes according to baseline predicted serum vitamin D
| N | Incident T2D | HR (95% CI) | |
|---|---|---|---|
| Main analysis Q4 vs. Q1a | 18,594 | 209 | 0.48 (0.26–0.88) |
| Excluding participants with cancer at baselineb | 18,103 | 198 | 0.48 (0.26–0.89) |
| Excluding participants with hypertension at baselinec | 16,631 | 113 | 0.28 (0.11–0.72) |
| Excluding participants with hypertriglyceridemia at baselined | 17,393 | 136 | 0.44 (0.20–0.99) |
| Excluding participants with hypercholesterolemia at baselinee | 15,446 | 114 | 0.50 (0.22–1.17) |
| Excluding extreme daily energy intake (< p1 or > p99) | 20,108 | 217 | 0.50 (0.27–0.90) |
| Excluding outliersf | 17,823 | 192 | 0.45 (0.24–0.86) |
| Including only participants with family history of T2D | 2854 | 80 | 0.34 (0.10–1.10) |
| Including only overweight participantsg | 5538 | 173 | 0.19 (0.07–0.56) |
| Including only participants with sedentary lifestyleh | 9297 | 135 | 0.28 (0.09–0.93) |
aAdjusted for sex, age, marital status, smoking status (current, former or never smoker), smoking pack-years, weight change, years of university, TV hours/day, family history of T2D, physical activity (MET-h/week), Trichopoulou’s 9-point score/Mediterranean dietary pattern, energy intake (kcal/day), sugar-sweetened beverage consumption (servings/day), snacking, following a special diet, prevalent hypertension, prevalent cancer, prevalent hypercholesterolemia, prevalent hypertriglyceridemia, obesity (kg/m2)
bWithout prevalent cancer adjustment
cWithout prevalent hypertension adjustment
dWithout prevalent hypertriglyceridemia adjustment
eWithout prevalent hypercholesterolemia adjustment
fWithout outliers located within ± 1.5 interquartile range of the average of predicted vitamin D
gParticipants with BMI ≥ 25 kg/m2 were included
hParticipants with sedentary lifestyle (MET-h/week < p50)