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. 2024 Mar 8;47(9):2313–2323. doi: 10.1007/s40618-024-02324-3

Table 3.

Sensitivity analyses: HR and 95% CI (Q4 vs. Q1) for incident type 2 diabetes according to baseline predicted serum vitamin D

N Incident T2D HR (95% CI)
Main analysis Q4 vs. Q1a 18,594 209 0.48 (0.26–0.88)
Excluding participants with cancer at baselineb 18,103 198 0.48 (0.26–0.89)
Excluding participants with hypertension at baselinec 16,631 113 0.28 (0.11–0.72)
Excluding participants with hypertriglyceridemia at baselined 17,393 136 0.44 (0.20–0.99)
Excluding participants with hypercholesterolemia at baselinee 15,446 114 0.50 (0.22–1.17)
Excluding extreme daily energy intake (< p1 or > p99) 20,108 217 0.50 (0.27–0.90)
Excluding outliersf 17,823 192 0.45 (0.24–0.86)
Including only participants with family history of T2D 2854 80 0.34 (0.10–1.10)
Including only overweight participantsg 5538 173 0.19 (0.07–0.56)
Including only participants with sedentary lifestyleh 9297 135 0.28 (0.09–0.93)

aAdjusted for sex, age, marital status, smoking status (current, former or never smoker), smoking pack-years, weight change, years of university, TV hours/day, family history of T2D, physical activity (MET-h/week), Trichopoulou’s 9-point score/Mediterranean dietary pattern, energy intake (kcal/day), sugar-sweetened beverage consumption (servings/day), snacking, following a special diet, prevalent hypertension, prevalent cancer, prevalent hypercholesterolemia, prevalent hypertriglyceridemia, obesity (kg/m2)

bWithout prevalent cancer adjustment

cWithout prevalent hypertension adjustment

dWithout prevalent hypertriglyceridemia adjustment

eWithout prevalent hypercholesterolemia adjustment

fWithout outliers located within ± 1.5 interquartile range of the average of predicted vitamin D

gParticipants with BMI ≥ 25 kg/m2 were included

hParticipants with sedentary lifestyle (MET-h/week < p50)