Fig. 2.
Naloxone blockade via IM administration 10 min prior to [11C]CFN injection. Representative Logan DVR images of the same NHP in baseline and naloxone pretreatment studies in (a) brain and (b) cervical spinal cord. (c) Box plot of Logan DVR for baseline, retest, and naloxone pretreatment, and (d) bar graph of %RO (mean ± standard deviation) in the different brain regions and cervical spinal cord. Statistical significance of p value calculated by paired t-test: **** p < 0.0001, *** p < 0.001, ** p < 0.01, and * p < 0.05