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. 2024 May 8;51(11):3252–3266. doi: 10.1007/s00259-024-06741-7

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — The globus pallidus internus was the most relevant PSP target region for [¹⁸F]PI-2620 PET imaging in previous studies ² and served as an exemplary region of interest. (A) Correlations of V_T values [ml/ccm] in the globus pallidus internus calculated with AIF and IDIF generated by manual and automated methods with confidence intervals of 95% (healthy controls: n = 8, PSP patients: n = 10, disease controls: n = 2). (B) Correlations of V_T ratio values [-] (reference region: inferior cerebellum) in the globus pallidus internus calculated with AIF and IDIF generated by manual and automated methods with confidence intervals of 95% (healthy controls: n = 8, PSP patients: n = 10, disease controls: n = 2). (C) Averaged V_T [ml/ccm] and V_T ratio [-] images with corresponding coefficient of variation [%] image of healthy controls (HC) (n = 15), patients with PSP (n = 15) and patients with AD (n = 10)