Table 1.
Demographic features of the cases with PCH and TCH
| PCH (n = 111) | TCH (n = 128) | p-value | Eutopic PCH (n = 67) | Eutopic TCH (n = 127) | p-value | |
|---|---|---|---|---|---|---|
| Current age (months)* | 76 (72–80) | 75 (70–79) | 0.112& | 76 (72–79) | 75 (70–79) | 0.391& |
| Female/male, n (%) | 58 (52.3)/53 (47.7) | 60 (46.9)/68 (53.1) | 0.407# | 29 (43.3)/38 (56.7) | 59 (46.5)/68 (53.5) | 0.572# |
| Parental consanguinity, n (%) | 16/63 (25.4) | 17/80 (21.3) | 0.559# | 12/39 (30.8) | 16/78 (20.5) | 0.220# |
| Perinatal history | ||||||
| Birth weight (grams)* | 3150 (2850–3510) | 3160 (2840–3500) | 0.825& | 3235 (2800–3500) | 3150 (2800–3500) | 0.816& |
| Gestational age (weeks)* | 39(38–40) | 39 (38–40) | 0.948& | 39 (38–40) | 39 (38–40) | 0.887& |
| Prematurity, n (%) | 16 (14.4) | 24 (18.8) | 0.444# | 9 (13.4) | 24 (18.9) | 0.395# |
| Hypoxia, n (%) | 3 (2.7) | 5 (3.9) | 0.724 ¶ | 1 (1.5) | 5 (3.9) | 0.665¶ |
| Admission to NICU, n (%) | 14 (12.6) | 14 (10.9) | 0.762# | 6 (8.9) | 14 (11) | 0.646# |
| Prolonged jaundice, n (%) | 18 (16.2) | 17 (13.3) | 0.595# | 9 (13.4) | 16 (12.6) | 0.870# |
| Congenital malformations, n (%) | 4 (3.6) | 5 (3.9) | 0.883¶ | 2 (3.0) | 5 (3.9) | 0.999¶ |
|
Family history Maternal history of thyroid disease, n (%) Hypothyroidism Graves disease/ATD Papillary thyroid carcinoma Family history of CH, n (%) |
15 (13.5) 14 (12.6) – 1 (0.9) 7 (6.3) |
7 (5.5) 6 (4.7) 1 (0.8) – 5 (3.9) |
0.054# 0.495# |
10 (14.9) 10 (14.9) – – 5 (7.5) |
6 (4.7) 5 (3.9) 1 (0.8) – 5 (3.9) |
0.014# 0.297# |
*Median (Q1-Q3)
¶Fisher’s exact test was used
#Chi-square test was used
&Mann–Whitney U test was used
TCH transient congenital hypothyroidism, PCH permanent congenital hypothyroidism, NICU neonatal intensive care unit, ATD antithyroid drug
Maternal history of thyroid disease was significantly higher in the eutopic PCH group