Table 2.
Clinical and laboratory features of the cases with PCH and TCH at the time of diagnosis
| PCH (n = 111) | TCH (n = 128) | p-value | Eutopic PCH (n = 67) | Eutopic TCH (n = 127) | p-value | |
|---|---|---|---|---|---|---|
| Initial NBS-TSH (µIU/mL)* | 32.8 (10.70–8.60) | 14.8 (9.30–26.0) | < 0.001& | 11.7 (7.5–62.3) | 15.3 (9.3–26.0) | 0.859& |
| Age at first NBS (days)* | 5 (4–8) | 5 (4–7) | 0.192& | 5.5 (4–8) | 5 (4–7) | 0.411& |
| Second NBS-TSH (µIU/mL)* | 19.10 (9.42–28.0) | 18.53 (9.85–33.5) | 0.711& | 18.29 (8.9–27.9) | 19.5 (10.2–33.7) | 0.470& |
| Age at second NBS (days)* | 14.5 (11–18.75) | 14 (12.25–17.20) | 0.916& | 16.0 (12.0–18.5) | 14 (12.0–17.0) | 0.576& |
| Initial serum TSH (µIU/mL)* | 56.62 (21.02–100) | 34.2 (20.32–84.12) | 0.027& | 39.0 (18.2–100) | 34.4 (20.4–83.4) | 0.620& |
| Initial serum FT4 (ng/dl)* | 0.76 (0.39–1.02) | 0.73 (0.55–0.98) | 0.151& | 0.82 (0.40–1.12) | 0.73 (0.56–0.98) | 0.937& |
| Time of the diagnosis (days)* | 19 (15–25) | 18 (12–25) | 0.578& | 18 (14.5–26.5) | 18 (13–25) | 0.740& |
| Tiroglobulin (ng/ml)*(n = 39) | 111 (19.8–455) | 347 (300–500) | 0.006& | 111 (24–500) | 347 (300–500) | 0.227& |
|
Iodine status Iodine deficiency, n (%) Normal, n (%) Iodine excess, n (%) |
11 (47.8) 10 (43.5) 2 (8.7) |
4 (30.8) 4 (30.8) 5 (38.4) |
0.146¶ |
4 (36.4) 7 (63.6) – |
4 (30.8) 4 (30.8) 5 (38.5) |
0.073¶ |
| Thyroid ultrasonography | ||||||
| Total thyroid volume (ml)* | 0.49 (0.06–1.02) | 0.77 (0.5–1.02) | < 0.001& | 0.78 (0.52–1.46) | 0.77 (0.51–1.0) | 0.317& |
|
Normal, n (%) Hyperplasia, n (%) Ectopy, n (%) Agenesis, n (%) Hypoplasia, n (%) Hemiagenesis, n (%) |
53 (47.7) 14 (12.6) 5 (4.5) 16 (14.5) 18 (16.2) 5 (4.5) |
116 (90.6) 11 (8.6) – – – 1 (0.8) |
< 0.001¶ |
53 (79.1) 14 (20.9) – – – – |
116 (91.3) 11 (8.7) – – – – |
0.010# |
| Initial LT4 dose (µg/kg/day)* | 10 (7.11–12.72) | 10 (6.7–12.5) | 0.527& | 10 (7.0–11.0) | 10 (7–13) | 0.635& |
| Time of the treatment initiation (days)* | 18 (14–25) | 18 (12.5–25) | 0.768& | 18 (14.5–26.5) | 18 (13–25) | 0.740& |
*Median (Q1–Q3)
¶Fisher’s exact test was used
#Chi-square test was used
&Mann-Whitney U test was used
TCH transient congenital hypothyroidism, PCH permanent congenital hypothyroidism, NBS newborn screening, TSH thyroid stimulating hormone, FT4 free thyroxine, LT4 L-thyroxine
In cases with PCH, initial NBS-TSH and initial serum TSH were significantly higher and total thyroid volume was significantly lower. The serum thyroglobulin level at the time of diagnosis was lower in the PCH group