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Low-Grade Chronic Inflammation, Skeletal Muscle Wasting, and Brain Impairments. The systemic inflammation triggers a disruptive cascade that impacts brain and skeletal muscle physiology and morphology and impairing behavior. IGF-1: Insulin like growth factor-1 mBDNF: mature brain-derived neurotrophic factor isoform; proBDNF: pro-brain-derived neurotrophic factor isoform; NMJ: neuromuscular junction.
