Table 5.

Factors in favor and against home introduction of milk

Factor	Milk ladder not recommended	Milk ladder might be considered for gradual home introduction
Age	5 years and older	Younger than 5 years
IgE-CMA	Prior anaphylaxis	No prior anaphylaxis
Non-IgE CMA	Severe FPIES with documented low blood pressure, fluid resuscitation, hospitalization	Food protein-induced allergic proctocolitis, food protein-induced enteropathy
Eliciting dose	Low previous reaction threshold to baked or no-baked CM, reactions to trace amounts or cross-contamination	High previous reaction threshold to baked or non-baked CM
Reactivity to baked milk	Reactions to baked milk	Ingestion of small amount of baked milk without symptoms
Asthma	Poor control	Optimal control
Laboratory tests	High and or increasing SPT wheal or serum CM-specific IgE levels	Small and or decreasing SPT wheal or serum CM-specific IgE levels
Adherence to chronic therapies, e.g., for asthma, eczema	Poor/sub-optimal	Adequate
Shared decisions	Caregivers apprehensive about the ladder approach, language or comprehension barrier	Caregivers seeking/accepting ladder approach, no language or comprehension barriers