Table 2.
Hazard ratios and 95% confidence intervals for lung cancer incidence across the 3 baseline eGFR groups
| Variables | Person-years | Incident cases | Incidence density (per 10,000 person-years) | Unadjusted model | Multivariate-adjusted model1 |
|---|---|---|---|---|---|
| eGFR (mL/min/1.73 m2) | |||||
| Group 1 (≥90) | 1,127,480.18 | 1,519 | 13.47 | 1.00 (reference) | 1.00 (reference) |
| Group 2 (≥60 to <90) | 2,021,331.03 | 3,481 | 17.22 | 1.28 (1.20, 1.36) | 1.26 (1.19, 1.35) |
| Group 3 (<60) | 321,615.57 | 757 | 23.54 | 1.75 (1.61, 1.91) | 1.72 (1.58, 1.89) |
| p for trend | <0.001 | <0.001 | |||
| Sex (female vs. male) | - | - | - | - | 0.56 (0.52, 0.61) |
| BMI | - | - | - | - | 0.93 (0.92, 0.94) |
| Fasting blood glucose | - | - | - | - | 1.00 (1.00, 1.00) |
| GGT | - | - | - | - | 1.00 (1.00, 1.00) |
| Smoking amount (pack-years) | - | - | - | - | 1.02 (1.02, 1.02) |
| Smoking status | |||||
| Never smoker | - | - | - | - | 1.00 (reference) |
| Former smoker | - | - | - | - | 0.75 (0.68, 0.82) |
| Current smoker | - | - | - | - | 1.18 (1.08, 1.29) |
| Alcohol consumption | - | - | - | - | 1.07 (0.99, 1.14) |
| Physical activity | - | - | - | - | 1.02 (0.95, 1.09) |
| COPD | - | - | - | - | 1.68 (1.59, 1.78) |
| Asthma | - | - | - | - | 1.40 (1.32, 1.49) |
eGFR, estimated glomerular filtration rate; BMI, body mass index; GGT, gamma-glutamyltransferase; COPD, chronic obstructive pulmonary disease.
1
The multivariate-adjusted model was adjusted for sex, BMI, fasting blood glucose, GGT, smoking amount (pack-years), smoking status, alcohol consumption, physical activity, COPD, and asthma; Age was not included in the multivariate-adjusted model.