Table 3.
Hazard ratios and 95% confidence intervals for lung cancer incidence across the 3 baseline eGFR groups, after stratification by urine protein level
| Variables | Urine protein level |
|||
|---|---|---|---|---|
| <2+ (n=353,224, 98.97%) |
≥2+ (n=3,669, 1.03%) |
|||
| Unadjusted model | Multivariate-adjusted model1 | Unadjusted model | Multivariate-adjusted model1 | |
| eGFR (mL/min/1.73 m2) | ||||
| Group 1 (≥90) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) |
| Group 2 (≥60 to <90) | 1.27 (1.20, 1.35) | 1.26 (1.18, 1.34) | 1.95 (0.95, 4.03) | 2.00 (0.97, 4.15) |
| Group 3 (<60) | 1.73 (1.58, 1.89) | 1.70 (1.56, 1.87) | 2.94 (1.40, 6.17) | 2.93 (1.37, 6.24) |
| p for trend | <0.001 | <0.001 | <0.001 | <0.001 |
| Sex (female vs. male) | - | 0.56 (0.52, 0.61) | - | 0.28 (0.13, 0.62) |
| BMI | - | 0.93 (0.92, 0.94) | - | 0.92 (0.85, 0.99) |
| Fasting blood glucose | - | 1.00 (1.00, 1.00) | - | 1.00 (1.00, 1.01) |
| GGT | - | 1.00 (1.00, 1.00) | - | 1.00 (0.99, 1.00) |
| Smoking amount (pack-years) | - | 1.02 (1.02, 1.02) | - | 1.00 (0.99, 1.02) |
| Smoking status | ||||
| Never smoker | - | 1.00 (reference) | - | 1.00 (reference) |
| Former smoker | - | 0.74 (0.68, 0.82) | - | 1.05 (0.51, 2.17) |
| Current smoker | - | 1.18 (1.08, 1.28) | - | 1.80 (0.89, 3.65) |
| Alcohol consumption | - | 1.06 (0.99, 1.14) | - | 1.47 (0.85, 2.52) |
| Physical activity | - | 1.02 (0.95, 1.09) | - | 1.09 (0.63, 1.91) |
| COPD | - | 1.69 (1.60, 1.79) | - | 1.19 (0.73, 1.96) |
| Asthma | - | 1.40 (1.32, 1.50) | - | 1.35 (0.78, 2.33) |
eGFR, estimated glomerular filtration rate; BMI, body mass index; GGT, gamma-glutamyltransferase; COPD, chronic obstructive pulmonary disease.
1
The multivariate-adjusted model was adjusted for sex, BMI, fasting blood glucose, GGT, smoking amount (pack-years), smoking status, alcohol consumption, physical activity, COPD, and asthma; Age was not included in the multivariate-adjusted model.