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. 2024 Sep 2;29:448. doi: 10.1186/s40001-024-02042-9

Table 1.

Comparison of patient characteristics between AML with NUP98-r and those without NUP98-r

Characteristics Patients with NUP98-r (n = 9) Patients without NUP98-r (n = 133) P value
Male, n (%) 6 (66.7%) 87 (65.4%) 0.775
Age, M (range) years 4.4 (1.5–14.2) 5.9 (0.3–18.0) 0.864
WBC, M (range) × 109/L 34.4 (3.3–375.2) 15.8 (1.1–557.2) 0.273
Hb, M (range) × g/L 94.0 (36.0–107.0) 88.5 (22.0–135.0) 0.826
PLT, M (range) × 109/L 90.0 (10.0–595.0) 62.0 (2.0–571.0) 0.607
BM blast (%) 75.0 (38.0–92.0) 69.5 (9.0–97.0) 0.717
Immunotyping
 CD33+ 9/9 (100%) 117/127 (92.1%) 1.000
 CD13+ 6/9 (66.7%) 86/127 (67.7%) 0.761
 MPO+ 4/9 (44.4%) 57/127 (44.9%) 0.748
 CD117+ 7/9 (77.8%) 106/127 (83.5%) 0.984
 HLA-DR+ 6/9 (66.7%) 103/126 (81.7%) 0.502
 CD34+ 6/9 (66.7%) 69/127 (54.3%) 0.710
 CD11b+ 2/9 (22.2%) 41/127 (32.3%) 0.798
 CD45+ 9/9 (100%) 125/127 (98.4%) 1.000
 CD15+ 4/9 (44.4%) 74/127 (58.3%) 0.644
 CD4+/CD7+ 4/9 (44.4%) 67/127 (52.8%) 0.891
 CD56+ 1/9 (11.1%) 46/126 (36.5%) 0.237
Morphology
 M0 0 (0%) 5 (3.8%) 1.000
 M1 0 (0%) 2 (1.5%) 1.000
 M2 4 (44.4%) 44 (33.1%) 0.739
 M4 1 (11.1%) 17 (12.8%) 0.710
 M5 3 (33.3%) 62 (46.6%) 0.668
 M6 0 (0%) 1 (0.8%) 1.000
 M7 0 (0%) 2 (1.5%) 1.000
 APL-like 1 (11.1%) 0 (0.0%) 0.063
Cytogenetics
 Normal karyotype 5/9 (55.6%) 30/131 (22.6%) 0.073
 Complex karyotype 3/9 (33.3%) 17/131 (12.8%) 0.232

AML acute myeloid leukemia, NUP98-r NUP98 rearrangement, WBC white blood cell, HB haemoglobin, PLT platelet, BM bone marrow