Table 2.
Univariate and multivariate Cox regression analysis of RFS in pediatric AML
| Variable | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| HR | P value | HR | P value | |
| WBC ≥ 100 × 109/L | 0.783 | 0.743 | ||
| MRD after one cycle induction ≥ 5% | 2.451 | 0.080 | ||
| MRD after two cycle induction ≥ 1 × 10–3 | 1.155 | 0.752 | ||
| Complex karyotype | 0.828 | 0.800 | ||
| NUP98-r | 7.934 | < 0.001 | 8.720 | < 0.001 |
| KMT2A aberration | 0.993 | 0.989 | ||
| RUNX1::RUNX1T1 fusion | 0.135 | 0.022 | ||
| WT1 mutation | 2.930 | 0.030 | 3.152 | 0.030 |
| KIT mutation | 0.290 | 0.199 | ||
| FLT3-ITD mutation | 2.394 | 0.109 | ||
| FLT3 mutation | 0.283 | 0.189 | ||
| NRAS mutation | 0.363 | 0.157 | ||
RFS relapse-free survival, AML acute myeloid leukemia, HR hazard ratio, WBC white blood cell, MRD minimal residual disease, NUP98-r NUP98 rearrangement