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. 2024 Apr 13;61(5):803–814. doi: 10.1177/03009858241241794

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© The Author(s) 2024

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Figure 4. — Graphs and photomicrograph representing the relative levels of gene expression by quantitative real-time PCR in ORF virus infected and healthy control lambs and kids. (a–e). Gene expression relative quantification of host vascular endothelial growth factor receptor 2 (VEGFR2), vascular endothelial growth factor receptor 1 (VEGFR1), vascular endothelial growth factor (VEGF), epidermal growth factor receptor (EGFR), and interleukin-6 (IL-6). Statistically significant overexpression was found only for VEGFR1, VEGFR2, and IL-6 when compared with the healthy controls. Values were normalized to the expression levels of the sheep 18s rRNA and β-actin (ACTB) and expressed as relative fold change compared to the expression levels of one of the healthy controls. (f) Representative image of the IL-6 mRNA localization in the dermis. In situ hybridization for IL-6 mRNA.