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Amino acid mutations occurring in L protein. The cartoon representation shows the position of amino acid residues (black sphere), highlighting the mutations >50% variant frequency shown in Table 3. The domains are described based on previous reports (19): RNA-dependent RNA polymerase (RdRp), cyan; poly-ribonucleotidyltransferase (PRNTase), green; connecting domain (CD), yellow; methyltransferase (MTase), orange; C-terminal domain (CTD), red.
