Figure 3: Dissemination of P. aeruginosa from the GI tract.
P. aeruginosa burden in organs of mice carrying PABL048. Mice were sacrificed at (A) day 3 (n = 10), (B) day 7 (n = 10) or (C) day 14 (n = 9) post-orogastric gavage with 107.4+/-0.2 CFU of PABL048, and bacterial CFU in the organs were enumerated by plating. The experiment was performed twice; combined results are shown. Each symbol represents one mouse. Solid horizontal lines indicate medians. The vertical dashed lines separate GI tract organs (left) from other organs (right). Symbols representing mice with dissemination from the GI tract are colored (one color/mouse). The horizontal dotted line indicates the limit of detection.