Figure 3.

(A) Jaccard coefficients comparing the hits across all pairs of cell lines using three different methods. Black line indicates the median Jaccard coefficient for each method. (B) Line plot showing the mean number of synthetic lethal pairs identified in all four, three, two, and one screens using the three methods. (C) Line plot showing the median percent sequence identity of all synthetic lethal pairs identified in all four, three, two, and one screens using the three methods. (D) Table displaying the ZdLFC score of common hits identified across all four screens. (E) Background-specific paralog synthetic lethals shown in all four cell lines. Gene pair CDK4/CDK6 was not included in the prototype library.