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[Preprint]. 2024 Aug 21:2024.08.19.608619. [Version 1] doi: 10.1101/2024.08.19.608619

Figure 6: Our campaign furnished a toolbox of chemical probes against SARS-CoV-2 nsp3-mac1.

Figure 6:

The table shows key physicochemical, in vitro ADME, and selectivity data for tool compounds. These tool compounds clearly reveal that nsp3-mac1 inhibition does not translate to antiviral activity.