Figure 2:

Development of GEM | A, The Spearman correlation between mutation burden and chronological age stratified by chromHMM annotations in CD34+ cells. B, The Spearman correlation between mutation burden and chronological age stratified by functional consequence as annotated by the variant effect predictor (VEP). C, The Spearman correlation between mutation burden and chronological age, stratified by quintiles of CADD scores. D, Plate annotation for the GEM statistical model. ${\theta }_0$ and are intercepts; ${\theta }_1$ reflects the association between log2 transformed value of $\sum z_{ij}$ and chronological age $Y_i$; $z_{ij}$ denotes the probability that the $jth$ mutation in the $ith$ individual is a true somatic mutation. X is a matrix of annotations.