Table 4.

Disorder and behavioral associations of top nodes by cell-type and behavioral set from MalaCards, OMIM, and GWAS catalogue.

Cell type		Top Node	Gene name	Mota P	Z-score	Rare Disorders	GWAS
Mature iGLUT	1	CNBP	Sterol-mediated transcriptional repression	2.9e-16	8.18	Myotonic Dystrophy, Neuromyotonia & axonal neuropathy (AR), Creutzfeldt-Jakob Disease, Deafness (AR), Fragie-X tremor/ataxia, ALS
		ANKRD36		1.95e-18	8.8
	2	FOXJ3		1.7e-17	8.5
		ATP6VOC		5.3e–44	−13.9	ASD, Epilepsy, NDD
	3	FOXJ3	Gene expression regulation/chromatin	1.9e-19	9.02		EA (rs35011283)
		SOX12	Implicated in cell fate decisions during development	1.6e-17	−8.52	Microphtalmia Syndromic 12 (neurological)	Memory performance (rs78532272)
	4	FOXJ3		7.9e-22	9.6
		ANKRD36	Ankyrin Repeat Domain 36	6.6-e26	−10.5	Neuropathy, Giant Axonal Nonsyndromic Deafness (AR)	SCZ (rs9631085), neuroimaging (rs11692435, rs167684, +6)
Mature iGABA	1	UBE2D4	Ubiquitin-Conjugating Enzyme E2 D4	1.2e-09	6.1
		PRKAG2	Protein Kinase AMP-Activated Non-Catalytic Subunit	6.7e-7	−4.97	Wolff-Parkinson-White Syndrome, Neuromuscular Disease, Specific Language Impairment. Microencephaly, Epilepsy	EA (rs1860735, rs2538046, rs4726070), ASD/SCZ (rs115136442), impulse control (rs2302532), BIP (rs7795096), memory (rs2536058)
	2	MYL3	BBB & immune cell trasnmigration	4e–12	6.9	Wolff-Parkinson-White Syndrome, Microencephaly, Epiliepsy
		TNFSF11		3.6e-10	−6.3	ID, NDD, developmental & epileptic encephalopathy, IBS,
	3	KIF1A	Axonal Transporter Of Synaptic Vesicles	8.8e-12	6.8	ID, ASD, neuropathy, Epilepsy, Spastic Ataxia, Cortical Dysplasia, Alacrima, Achalasia, and Impaired ID Syndrome	Insomnia (rs10196604, rs4455151)
		UNC5C	Netrin Receptor	3.98e-8	−5.5	Alzheimer Disease, Familial 1	Insomnia (rs371745379), wellbeing (rs116984513), OCD (rs17384439), cognition (rs3846455), unipolar depression (rs6822806)
	4	UBE2D4		8.5e-13	7.2
		UBC		1.70–10	−6.4	Parkinson’s disease, epilepsy, muscular dystrophy	Sleep duration (rs10773112), AD (rs78184510),