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[Preprint]. 2024 Aug 24:2024.08.23.609190. [Version 1] doi: 10.1101/2024.08.23.609190

Table 1.

Disorder and behavioral associations of top convergent up and down-regulated genes by cell-type.

Coll-type Top Meta Gene Mota P Z-score Rare Disorders GWAS and behavioral associations
NPCs AGAP4 1.2e-14 7.71 Mitochondrial Complex 1 Deficiency
CYTL1 7.8e-9 −5.77 Muscular Trophy (AD) T1D, UC, CD, T2D, psoriasis, celiac, autoimmune disease, thyroid disease, ankylosing spondylitis (rs7672495)
Int. iGLUTs MBD2 1.2e-15 8.01 Cerebellar Ataxia, Deafness, Narcolepsy (AD) Breast Cancer Allergic disease, psoriasis, neuroticism, hoarding disorder, executive funcion measurement, memory function
SHOX 2.9e-l3 −7.30 Turner Syndrome, Dysplasia
Mat. iGLUTs MAP3K14 6.2e-36 12.52 Immunodeficlency (AR; X-linked), Ectodermal Dysplasia. Noonan Syndrome PD, neuroticism, neuroimaging, unipolar depression, mood disorder, anxiety, cognitive function, MS, asthma, allergic disease.
JMY 2.4e 44 −13.97 Galloway Mowat Syndrome (AR; X-linked) T2D
Mat. iGABAs GPR83 1.36–17 −8.54 testosterone measurement, free androgen index, age at menarche, anxiety like-behaviors
UBE2D4 3.9e-2l 9.44 Brachydactyly, Type E2 (BDE2) (AD)

Autosomal dominate (AD), Parkinson’s disease (PD), multiple sclerosis (MS), ulcerative colitis (UC), type-1 diabetes (T1D), type=2 diabetes (T2D), Crohn’s disease (CD)

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