Table 1.
Coll-type | Top Meta Gene | Mota P | Z-score | Rare Disorders | GWAS and behavioral associations |
---|---|---|---|---|---|
NPCs | AGAP4 | 1.2e-14 | 7.71 | Mitochondrial Complex 1 Deficiency | |
CYTL1 | 7.8e-9 | −5.77 | Muscular Trophy (AD) | T1D, UC, CD, T2D, psoriasis, celiac, autoimmune disease, thyroid disease, ankylosing spondylitis (rs7672495) | |
Int. iGLUTs | MBD2 | 1.2e-15 | 8.01 | Cerebellar Ataxia, Deafness, Narcolepsy (AD) Breast Cancer | Allergic disease, psoriasis, neuroticism, hoarding disorder, executive funcion measurement, memory function |
SHOX | 2.9e-l3 | −7.30 | Turner Syndrome, Dysplasia | ||
Mat. iGLUTs | MAP3K14 | 6.2e-36 | 12.52 | Immunodeficlency (AR; X-linked), Ectodermal Dysplasia. Noonan Syndrome | PD, neuroticism, neuroimaging, unipolar depression, mood disorder, anxiety, cognitive function, MS, asthma, allergic disease. |
JMY | 2.4e 44 | −13.97 | Galloway Mowat Syndrome (AR; X-linked) | T2D | |
Mat. iGABAs | GPR83 | 1.36–17 | −8.54 | testosterone measurement, free androgen index, age at menarche, anxiety like-behaviors | |
UBE2D4 | 3.9e-2l | 9.44 | Brachydactyly, Type E2 (BDE2) (AD) |
Autosomal dominate (AD), Parkinson’s disease (PD), multiple sclerosis (MS), ulcerative colitis (UC), type-1 diabetes (T1D), type=2 diabetes (T2D), Crohn’s disease (CD)