Table 3:
Top down-regulated pathways assessed by GSEA.
| GENE SET NAME | GENE SET SIZE | NORMALIZED ENRICHMENT SCORE | FDR q-val |
|---|---|---|---|
| RESPONSE_OF_EIF2AK4_GCN2_TO_AMINO_ACID_DEFICIENCY | 97 | −2.500622 | <0.0001 |
| PROCESSING_OF_CAPPED_INTRON_CONTAINING_PRE_MRNA | 272 | −2.3206754 | <0.0001 |
| MRNA_SPLICING | 206 | −2.2384663 | <0.0001 |
| CELLULAR_RESPONSE_TO_STARVATION | 146 | −2.1140559 | 2.65E-04 |
| TRANSLATION | 265 | −2.1280956 | 3.03E-04 |
| RESPONSE_OF_EIF2AK1_HRI_TO_HEME_DEFICIENCY | 15 | −2.1524508 | 3.54E-04 |
| MITOTIC_SPINDLE_CHECKPOINT | 105 | −2.1535172 | 4.24E-04 |
| MITOTIC_PROMETAPHASE | 188 | −2.1807008 | 5.30E-04 |
| RESOLUTION_OF_SISTER_CHROMATID_COHESION | 113 | −2.0826728 | 0.00124505 |
| HOMOLOGY_DIRECTED_REPAIR | 97 | −2.0792227 | 0.00136852 |
| UNFOLDED_PROTEIN_RESPONSE_UPR | 87 | −2.0685549 | 0.00161693 |
| HATS_ACETYLATE_HISTONES | 74 | −2.0624247 | 0.00167453 |
| EPIGENETIC_REGULATION_OF_GENE_EXPRESSION | 122 | −2.0360024 | 0.00300752 |
| TRNA_PROCESSING_IN_THE_NUCLEUS | 56 | −2.0373957 | 0.00323887 |
| DNA_DOUBLE_STRAND_BREAK_REPAIR | 127 | −2.0197442 | 0.00574582 |
| TRNA_PROCESSING | 102 | −2.0040476 | 0.00739763 |
| TRANSPORT_OF_MATURE_TRANSCRIPT_TO_CYTOPLASM | 79 | −2.0042493 | 0.00746344 |
| MITOCHONDRIAL_TRANSLATION | 91 | −1.9900748 | 0.00848744 |
| METABOLISM_OF_FOLATE_AND_PTERINES | 16 | −1.9968468 | 0.00861588 |