Figure 3.
Overlap between FTLD atrophy correlated genes and HAR genes. (A) HARs are conserved genomic loci which have undergone accelerated divergence in the human evolutionary lineage. (B) Genes correlating with atrophy in FTLD-TDP had 808 genes in common with HAR genes, (C) while genes correlating with atrophy in FTLD-tau had 560 genes in common with HAR genes. Both overlaps were unlikely to occur by chance when compared to a background set of brain-expressed genes. ***P < 0.0005. (A) adapted with permission from Doan et al.7 and Wei et al.45 FTLD = frontotemporal lobar degeneration.