Skip to main content
. 2024 Jun 28;147(9):3032–3047. doi: 10.1093/brain/awae205

Figure 5.

Figure 5

HAR and cryptic splicing genes overlap. (A) Comparing the human accelerated region (HAR) and cryptic splicing (CS) gene lists, including those derived from induced pluripotent stem cell (iPSC)-derived neurons and from human patient tissues (HPT), 37 total genes were shared. Fisher's exact test was used to determine whether gene sets overlapped at a rate greater than expected by chance. We then explored the overlap between CS-HAR genes and genes correlating with atrophy in FTLD-TDP or FTLD-tau. (B) Twenty-three genes were shared between CS-HAR genes and genes correlating with atrophy in FTLD-TDP. This overlap did not reach significance (P = 0.17). (C) Fourteen genes were shared between CS-HAR genes and genes correlating with atrophy in FTLD-tau, with this overlap not being significant (P = 0.98). **P < 0.005. FTLD = frontotemporal lobar degeneration.