TABLE 1.
Summary of the Demographic and Pathologic Data, Type of NTRK-Rearrangement, and Centrally Reviewed Images on 17 Cases of Pediatric Tumors
| Case No. | Sex | Age at Diagnosis, Months | Pathologic Diagnosis | Presence of Metastasis at Diagnosis | Type of Fusion Detected by NGS | Images Centrally Reviewed? |
|---|---|---|---|---|---|---|
| 1 | M | 53.9 | WHO grade IV analogous malignant glioneuronal tumor | No | ETV6-NTRK3 | Yes |
| 2 | F | 13.3 | Infantile fibrosarcoma | No | TPM3-NTRK1 | No |
| 3 | M | 10.9 | Pediatric high-grade glioma | No | TPR-NTRK1 | Yes |
| 4 | F | 8.5 | Grade II diffuse astrocytoma | No | STRN-NTRK2 | Yes |
| 5 | M | 14.3 | Infantile fibrosarcoma | No | ETV6-NTRK3 | Yes |
| 6 | F | 34.4 | Peripheral nerve sheath sarcoma | No | TPM3-NTRK1 | Yes |
| 7 | M | 159.5 | Diffuse glioneuronal tumor with similar oligodendroglial features and nuclear clusters | No | ETV6-NTRK3 | Yes |
| 8 | M | 3.3 | Infantile fibrosarcoma | Yes | TPM3-NTRK1 | No |
| 9 | M | 7.4 | Infantile fibrosarcoma | No | ETV6-NTRK3 | Yes |
| 10 | F | 8.8 | Neuroblastoma | No | SCAPER-NTRK3 | Yes |
| 11 | F | 39.7 | Low-grade soft tissue sarcoma, NOE | No | TPM3-NTRK1 | Yes |
| 12 | F | 8.6 | Infantile fibrosarcoma | No | TPM3-NTRK1 | Yes |
| 13 | M | 0.1 | Infantile fibrosarcoma | No | ETV6-NTRK3 | Yes |
| 14 | M | 1.5 | Infantile fibrosarcoma | No | ETV6-NTRK3 | Yes |
| 15 | M | 40.1 | Mesenchymal spindle cell sarcoma/malignant peripheral nerve sheath tumor | No | TPM3-NTRK1 | Yes |
| 16 | M | 3.2 | Infantile fibrosarcoma | No | TPR-NTRK1 | Yes |
| 17 | M | 90.8 | Low-grade glioma | No | NOTCH2NL-NTRK1 | No |
Abbreviations: F, female; M, male; NGS, next-generation sequencing; NOE, not otherwise specified; NTRK, neurotrophic tropomyosin receptor kinase.