Comparison 2. Whole brain radiotherapy + teniposide and cisplatin: sequential versus concomitant.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Survival at 18 months	1	39	Odds Ratio (M‐H, Fixed, 95% CI)	2.83 [0.48, 16.81]
2 Complete brain metastases response	1	39	Risk Ratio (M‐H, Fixed, 95% CI)	1.11 [0.45, 2.70]
3 Partial short‐term response rates	1	39	Risk Ratio (M‐H, Fixed, 95% CI)	0.82 [0.38, 1.75]
4 Myelosuppression with III–IV leukopenia	1	39	Risk Ratio (M‐H, Fixed, 95% CI)	8.42 [1.16, 61.10]
5 III‐IV anemia level	1	39	Risk Ratio (M‐H, Fixed, 95% CI)	0.16 [0.02, 1.20]
6 III‐IV thrombocytopenia level	1	39	Risk Ratio (M‐H, Fixed, 95% CI)	0.11 [0.01, 1.84]
7 III‐IV leukopenia level	1	39	Risk Ratio (M‐H, Fixed, 95% CI)	0.12 [0.02, 0.86]
8 Thrombocytopenia	1	39	Risk Ratio (M‐H, Fixed, 95% CI)	0.40 [0.17, 0.91]
9 III‐IV nausea and vomiting level	1	39	Risk Ratio (M‐H, Fixed, 95% CI)	0.11 [0.01, 1.84]
10 III‐IV stomatitis level	1	39	Risk Ratio (M‐H, Fixed, 95% CI)	0.32 [0.01, 7.35]