Figure 4.

Neutrophil degranulation is enhanced in patients with LN. Neutrophil degranulation was assessed by untreated/basal cell surface expression of markers for secretory vesicles (CD35; n=15 LN, n=14 control), specific granules (CD66; n=15 LN, n=13 control), and azuophilic granules (CD63; n=22 LN, n=13 control) by flow cytometry. Statistical analysis comparing the two independent groups was performed by Mann–Whitney tests with post hoc Bonferroni correction for multiple comparisons and P values shown. Data were represented as mean±SD. MFI, mean fluorescence intensity.