Table 1.
Immune-related hepatitis severity grading criteria
| Lab | ULN | Grade 2 threshold | Grade 2 value | Grade 3 threshold | Grade 3 value | Grade 4 threshold | Grade 4 value |
|---|---|---|---|---|---|---|---|
| AST | 33 | 3×ULN | 99 | 5×ULN | 165 | >20×ULN | 660 |
| ALT | 48 | 3×ULN | 144 | 5× ULN | 240 | >20×ULN | 960 |
| AP | 122 | 2.5×ULN | 305 | 5×ULN | 610 | >20×ULN | 2440 |
| Total bilirubin | 1.3 | 1.5×ULN | 1.95 | 3× ULN | 3.9 | >10×ULN | 13 |
| Albumina | 3.5 | 3.0 | 2.0 | N/A |
Thresholds for irH severity grade as defined by NCI Common Terminology Criteria for Adverse Events V5, and the corresponding laboratory value
ALT alanine transaminase, AP alkaline phosphatase, AST aspartate transaminase, irH immune-related hepatitis, NA not applicable, NCI National Cancer Institute, ULN upper limit of normal
a
Albumin thresholds reported as the lower limit of normal