Table 2A.
Univariate and multivariate Cox analyses: neutrophil engraftment at day 30 post-HCT.
| Risk factors | Univariate | Multivariate | ||
|---|---|---|---|---|
| Hazard ratio (95% CI) | p | Hazard ratio (95% CI) | p | |
|
DSA
pos vs neg |
0.52 (0.28-0.95) | 0.02 | 0.65 (0.37-1.13) | 0.12 |
|
Disease
MFI vs AL |
0.36 (0.23-0.57) | <0.0001 | 0.48 (0.27-0.86) | 0.01 |
| Conditioning RIC vs ABL | 0.73 (0.53-0.99) | 0.04 | 0.87 (0.61-1.23) | 0.44 |
| Stem cell source PBSC vs others | 0.7 (0.45-1.34) | 0.3 | – | – |
|
Disease status at transplant
No CR vs CR |
0.44 (0.33-0.60) | <0.0001 | 0.47 (0.31-0.71) | 0.0004 |
|
Donor
SIB vs UD SIB vs Haplo |
0.57 (0.39-0.85) 0.40 (0.25-0.62) |
0.005
0.0001 |
0.6 (0.39-0.90) 0.46 (0.28-0.75) |
0.01
0.001 |
| CD34+ cell continuous | 1.11 (1.04-1.17) | 0.0003 | 1.12 (1.06-1.19) | P<0.0001 |
|
Age
continuous |
0.98 (0.97-0.99) | 0.003 | 0.99 (0.97-1.00) | 0.10 |
| Recipient sex Female vs male | 0.98 (0.62-1.39) | 0.7 | - | - |
|
GvHD prophylaxis
PTCY vs others |
0.55 (0.20-1.34) | 0.24 | - | - |
MFI, myelofibrosis; AL, acute leukemia; RIC, reduced intensity conditioning regimen; ABL, myeloablative conditioning regimen; PBSC, peripheral blood stem cells; SIB, sibling donor; UD, unrelated donor; HAPLO, haploidentical donor.
Risk factors affecting neutrophil engraftment failure at 30 days after HCT: DSA positivity (p = 0.02), disease type (p = 0.01), disease status (p < 0.0001), donor type (p= 0.0001), conditioning regimen (p = 0.04), age at transplant (p =0.003). Multivariate analysis confirmed the role of disease type (p <0.0001), disease status (p = 0.0004), donor type (p= 0.001), and number of CD34+ cells infused (p <0.0001).