Table 2B.
Univariate and multivariate Cox analyses: platelet engraftment at day 30 post-HCT.
| Risk factors | Univariate | Multivariate | ||
|---|---|---|---|---|
| Hazard ratio (95% CI) | p | Hazard ratio (95% CI) | p | |
|
DSA
pos vs neg |
0.40 (0.22-0.72) | 0.02 | 0.43 (0.23-0.82) | 0.01 |
|
Disease
MFI vs AL |
0.52 (0.32-0.82) | 0.005 | 0.62 (0.34-1.11) | 0.11 |
|
Conditioning
RIC vs ABL |
0.7 (0.50-0.97) | 0.03 | 0.89 (0.56-1.41) | 0.6 |
|
Stem cell source
PBSC vs others |
0.52 (0.19-1.40) | 0.19 | – | – |
|
Disease status at transplant
no CR vs CR |
0.52 (0.42-0.77) | 0.0004 | 0.58 (0.38-0.90) | 0.01 |
|
Donor
SIB vs UD SIB vs Haplo |
0.66 (0.38-1.17) 0.4 (0.27-0.71) |
0.1 0.0009 |
1.10 (0.71-1.70) 0.70 (0.42-1.16) |
0.65 0.17 |
|
CD34+ cell
continuous |
1.14 1.076-1.20) | <0.0001 | 1.17 (1.10-1.24) | <0.0001 |
|
Age
continuous |
0.9 (0.5-0.9) | <0.0001 | 0.97 (0.96-0.99) | <0.0001 |
|
Recipient sex
Female vs male |
0.93 (0.62-1.39) | 0.7 | - | - |
|
GvHD prophylaxis
PTCY vs others |
0.78 (0.25-2.46) | 0.67 | - | - |
MFI, myelofibrosis; AL, acute leukemia; RIC, reduced intensity conditioning regimen; ABL, myeloablative conditioning regimen; PBSC, peripheral blood stem cells; SIB, sibling donor; UD, unrelated donor; HAPLO, haploidentical donor.
Risk factors affecting platelets engraftment failure at 30 days after HCT: DSA positivity (p = 0.02), disease type (p =0.005), disease status (p=0.0004), donor type (p= 0.0009), conditioning regimen (p = 0.03), age at transplant (p <0.0001), and number of CD34+ cells infused (p < 0.0001). Multivariate analysis confirmed the role of DSA positivity (p=0.01), disease status (p=0.01) age (p < 0.0001) and number of CD34+ cells infused (p < 0.0001).