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. 2024 Feb 9;29(6):1869–1881. doi: 10.1038/s41380-024-02442-7

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — A Correlation between subject-level functional (red) and structural (blue) hub vulnerability of cortical alterations and PANSS general scores (r_func = 0.21, p_Bonf < 0.0001, r_struc = 0.13, p_Bonf = 0.01). B Correlation between subject-level functional (red) and structural (blue) hub vulnerability of cortical alterations and PANSS total scores (r_func = 0.10, p_Bonf = 0.001, r_struc = 0.09, p_Bonf = 0.004). C Correlations between subject-level functional (red) and structural (blue) epicenter likelihood and PANSS general scores. Significant associations were only found for functional epicenters spanning from sensory-motor areas to cingulate gyrus and insula (all r > .18, p_Bonf < 0.05). D Correlations between subject-level functional (red) and structural (blue) epicenter likelihood and PANSS total scores. Significant associations were found for functional epicenters in the bilateral somatosensory and motor cortices extending to supramarginal gyrus (in blue) as the only structural epicenter ((all r > 0.11, p_Bonf < 0.05).