Fig. 1.

(a) Schematic diagram of the experimental procedure. The arrowheads indicate the intravenous injection of HBSS, a cocktail of AAV(PHP.eB)-pGFAP-mCherry and AAV(PHP.eB)-pGFAP-CasRx as a control vector, or a cocktail of AAV(PHP.eB)-pGFAP-mCherry and AAV(PHP.eB)-pGFAP-CasRx-SgRNA-Ptbp1. (b) Bederson’s score, (c) the rotarod test, and (d) elevated body swing test (EBST) were compared between the three groups. (e) The examination time between a novel object and a familiar object in the novel object recognition test (NORT) was compared between groups. Note that the CasRx-Ptbp1 group showed a significant increase in the novel object time compared with the familiar object time (*p < 0.05). P-values < 0.05 were considered statistically significant.