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. 2024 Sep 3;15:7666. doi: 10.1038/s41467-024-51453-z

Fig. 1. Quantification of serum-soluble mediators on day (D)0, D7, and D63 after prime vaccination.

Fig. 1

Quantification of IL-18, IP-10, and TRAIL (pg/mL) in the serum of 92 vaccinated individuals at D0, D7, and D63 post vaccination (n = 29 placebo (grey), n = 28 Ad26-MVA (red), n = 26 rVSV (blue), n = 9 rVSV-booster (green)). The median values ± IQRs are shown. The box plots display the median (central line), the first and third quartiles (boxes), and the whiskers show 1.5 fold the interquartile range (IQR) above and below the boxes. Two-sided Wilcoxon Mann Whitney tests were used for comparisons between the active vaccine arms and the pooled placebo arms. FDR (Benjamini-Hochberg) method was used to adjust for test multiplicity. The exact p-values for IL-18, IP-10, and TRAIL at D7 in the comparison between the placebo group (grey) and the rVSV group (blue) are p = 0.047, p = 1.153e-07, and p = 0.033, respectively. Source data are provided as a Source Data file.