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. 2024 Sep 3;14:20455. doi: 10.1038/s41598-024-70992-5

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© This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2024

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Fig.12 — Gross Pathology and DOX Distribution of POL with DOX Injected into Tissue with MSHN. (A) Photograph of bovine liver tissue injected with POL containing DOX (2mg/mL) (n = 1) and cut into seven blocks. Black arrows indicate intravasation of POL with DOX, while red arrows denote localized deposition of POL with DOX. (B) Optical imaging of DOX fluorescence for the seven tissue blocks depicted in (A). Lines drawn correspond to ten regions colored differently, showing DOX radiant efficiency ([p/s/cm²/sr]/[µW/cm²]) over distance within the tissue blocks from (A) and (B). (C) Optical imaging showing DOX distribution along the short (1) and long axes (2) following POL containing DOX (2mg/mL) for localized injections with MSHN (n = 4). Sections (3–12) display optical imaging distribution over distance for the ten regions outlined in (B), represented by colored lines, for a representative POL injection containing DOX in bovine tissue (n = 1, selected from four injections performed with MSHN). Legend: Black arrows: Intravasation of POL with DOX; Red arrows: Localized deposition of POL with DOX, and (*) Depicts injection core.

Fig.12 — Gross Pathology and DOX Distribution of POL with DOX Injected into Tissue with MSHN. (A) Photograph of bovine liver tissue injected with POL containing DOX (2mg/mL) (n = 1) and cut into seven blocks. Black arrows indicate intravasation of POL with DOX, while red arrows denote localized deposition of POL with DOX. (B) Optical imaging of DOX fluorescence for the seven tissue blocks depicted in (A). Lines drawn correspond to ten regions colored differently, showing DOX radiant efficiency ([p/s/cm²/sr]/[µW/cm²]) over distance within the tissue blocks from (A) and (B). (C) Optical imaging showing DOX distribution along the short (1) and long axes (2) following POL containing DOX (2mg/mL) for localized injections with MSHN (n = 4). Sections (3–12) display optical imaging distribution over distance for the ten regions outlined in (B), represented by colored lines, for a representative POL injection containing DOX in bovine tissue (n = 1, selected from four injections performed with MSHN). Legend: Black arrows: Intravasation of POL with DOX; Red arrows: Localized deposition of POL with DOX, and (*) Depicts injection core.