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. 2024 Aug 1;56(8):1703–1716. doi: 10.1038/s12276-024-01279-y

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© This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2024

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Fig. 1 — The human IL-33 protein consists of a nuclear localization domain (amino acids 1–65), an activation domain (amino acids 66–111), and an IL-1-like cytokine domain. The IL-33 protein sequences surrounding the cleavage sites for mast cell proteases (chymase and granzyme B) and neutrophil cell proteases (elastase and cathepsin G) are shown. The figure was created with BioRender.com.