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. 2024 Aug 1;56(8):1703–1716. doi: 10.1038/s12276-024-01279-y

Fig. 3. IL-3399–270 is a more potent regulator of angiogenic events compared to other IL-33 mature forms.

Fig. 3

a Quiescent HRMVECs were treated with or without IL-3395–270, IL-3399–270, IL-33109–270, and IL-33112–270 (20 ng/mL), and cell proliferation was measured by a BrdU cell proliferation assay. b Cell migration was measured using a wound healing assay using all the same conditions as described in (a). c A spheroid assay was used to evaluate sprouting in HRMVECs, and images were captured after 2 days under a Zeiss LSM800 microscope. d Tube formation was assessed using growth factor-reduced Matrigel using the all the same conditions as described in (a). The bar graphs show the quantitative analysis of 3 independent experiments, expressed as the mean ± SD. *p < 0.05 vs. control. The scale bar represents 200 μm in (c).