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. 2024 Aug 1;56(8):1703–1716. doi: 10.1038/s12276-024-01279-y

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© This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2024

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Fig. 4 — Quiescent HRMVECs were treated with or without IL-33_95–270, IL-33_99–270, IL-33_109–270, and IL-33_112–270 (20 ng/mL), and total cellular RNA was extracted and subjected to mRNA sequencing. a Venn diagram showing the number of angiogenic genes regulated by IL-33_95–270, IL-33_99–270, IL-33_109–270, and IL-33_112–270 compared to the control. b Heatmap showing the expression profile of angiogenic genes regulated by IL-33_95–270 in HRMVECs. c Heatmap showing the expression profile of angiogenic genes regulated by IL-33_99–270 in HRMVECs. d Heatmap showing the expression profile of angiogenic genes regulated by IL-33_109–270 in HRMVECs. e Heatmap showing the expression profile of angiogenic genes regulated by IL-33_112–270 in HRMVECs. The differentially expressed genes in the heatmap that were regulated only by specific mature versions of IL-33 are highlighted in red.