Table 1. Baseline characteristics of the dataset.
| Characteristic | Baseline (n=395) | 12 months (n=395) | 24 months (n=395) | |
|---|---|---|---|---|
| Age (yr) | 72.6±7.3 | - | - | |
| Sex, female | 160 (40.5) | - | - | |
| Education (yr) | 16.1±2.8 | - | - | |
| APOE ε4 carrier | 192 (48.6) | - | - | |
| Race, white | 372 (94.2) | - | - | |
| Race, black | 10 (0.02) | - | - | |
| Race, others | 13 (0.03) | - | - | |
| Married | 305 (77.2) | - | - | |
| Widowed | 46 (0.12) | - | - | |
| Divorced | 36 (0.09) | - | - | |
| Never married or unknown | 8 (6+2) (0.02) | - | - | |
| MRI | ||||
| Hippocampus | 6806.8±1139.1 | - | - | |
| Entorhinal cortex | 3508.9±773.2 | - | - | |
| Fusiform gyrus | 17681.6±2710.3 | - | - | |
| NP test score | ||||
| MMSE | 27.7±1.7 | 27.2±2.5 | 26.5±3.3 | |
| ADAS13 | 16.3±6.4 | 16.7±7.9 | 18.5±9.6 | |
| mPACCdigit | -6.1±3.7 | -6.2±5.4 | -7.3±6.5 | |
| mPACCtrailsB | -5.7±3.6 | -5.9±5.1 | -6.8±6.1 | |
| RAVLT, immediate | 34.3±10.1 | 33.8±11.1 | 32.6±12.1 | |
| RAVLT, learning | 4.2±2.5 | 3.9±2.6 | 3.6±2.7 | |
| RAVLT, forgetting | 4.8±2.4 | 4.7±2.6 | 4.8±2.6 | |
| LDELTOTAL | 5.7±3.4 | 6.7±5.1 | 6.5±5.5 | |
| DIGITSCOR | 38.6±11.2 | 38.2±12.6 | 36.8±13.4 | |
| TRABSCOR | 110.0±62.3 | 116.0±70.1 | 119.7±75.8 | |
| FAQ | 3.3±4.3 | 4.7±5.7 | 6.3±7.3 | |
Data are mean±standard deviation or n (%) values.
ADAS13, 13-item cognition subscale of the Alzheimer’s Disease Assessment Scale; DIGITSCOR, Digit Span; FAQ, Functional Activities Questionnaire; LDELTOTAL, Delayed-Recall Total; MMSE, Mini-Mental State Examination; mPACC, modified Preclinical Alzheimer Cognitive Composite; MRI, magnetic resonance imaging; NP, neuropsychological; RAVLT, Rey’s Auditory Verbal Learning Test; TRABSCOR, Trail-Making Test B time to complete.