Figure 5.

Dietary patterns differentially shift tumor and mammary gland (MG) metabolism. A, Laurate significantly increased in MG from coconut oil (CO)-fed mice. B, Laurate significantly increased in tumors from the CO-fed mice. C, MG palmitate levels displayed differential shifts with diet. D, Tumor palmitate levels displayed differential shifts with diet. Arachidate levels in (E) MG and (F) tumor tissue. G, oleate was significantly elevated in high sugar (HS)-fed mice and significantly decreased in flaxseed oil (FO) and safflower oil (SO)-fed mice (H). No significant differences in oleate were observed in tumor tissue. Eicosapentaenoate (EPA) was significantly elevated in (I). MG and (J) tumor tissue in FO-fed mice. K, Docosapentaenoate (DPA) was significantly elevated in MG from FO-fed mice. L, Tumor levels of DPA were significantly elevated with the FO diet. Differential shifts in docosahexaenoate (DHA) were observed in (M) MG and (N) tumor tissue. Linolenate significantly increased with FO consumption in both (O) MG and (P) tumor tissue. Linoleate levels significantly increased with SO consumption in both (Q) MG and (R) tumor tissue. S, Significant differences were observed across diets in MG arachidonate levels. T, Minimal shifts were observed in tumor arachidonate levels across the different diets. *, P < 0.05; n = 5 per group. One-way ANOVA with Tukey post-hoc analysis.