Table 2.
Outcome | Estimate [95% interval] |
|||
---|---|---|---|---|
No surveillance | Universal US + AFP surveillance | Risk-stratified surveillance | Precision surveillance | |
Lifetime prevalence of HCC | 20.8% [20.7%–20.9%] | 20.8% [20.6%–20.9%] | 20.8% [20.6%–20.9%] | 20.7% [20.6%–20.9%] |
Total number of surveillance tests per 100,000 population | – | 1,899,075 [1,894,575–1,903,574] | 1,404,947 [1,400,556–1,409,337] | 1,697,193 [1,692,703–1,701,682] |
Number of HCC cases detected per 100,000 population | 11,650 [11,480–11,820] | 17,387 [17,141–17,633] | 16,859 [16,607–17,110] | 17,403 [17,158–17,649] |
Mode of detection, % | ||||
Incidental detection | 100.0% | 18.5% | 23.8% | 18.7% |
Surveillance detection | 0.0% | 81.5% | 76.2% | 81.3% |
Stage at diagnosis, N (%) | ||||
Stage A | 4434 (38.0%) | 10,972 (63.2%) | 10,752 (63.8%) | 11,754 (67.6%) |
Stage B | 4355 (37.4%) | 5573 (32.0%) | 5073 (30.0%) | 4805 (27.6%) |
Stage C | 2699 (23.2%) | 772 (4.4%) | 953 (5.6%) | 773 (4.4%) |
Stage D | 161 (1.4%) | 70 (0.4%) | 80 (0.4%) | 71 (0.4%) |
Risk group, N (%) | ||||
Low-risk | ||||
Early stage (stage A) | 508 (37.2%) | 1319 (63.6%) | 508 (37.2%) | 1046 (58.6%) |
Late stages (stages B-D) | 856 (62.8%) | 756 (36.4%) | 856 (62.8%) | 739 (41.4%) |
Intermediate-risk | ||||
Early stage (stage A) | 2203 (38.2%) | 5428 (63.2%) | 5428 (63.2%) | 5885 (67.5%) |
Late stages (stages B-D) | 3571 (61.8%) | 3157 (36.8%) | 3157 (36.8%) | 2835 (32.5%) |
High-risk | ||||
Early stage (stage A) | 1723 (38.2%) | 4225 (62.8%) | 4816 (69.7%) | 4824 (69.9%) |
Late stages (stages B-D) | 2789 (61.8%) | 2502 (37.2%) | 2094 (30.3%) | 2075 (30.1%) |
Surveillance efficiency, number of surveillance-detectedcases per 1000 surveillance tests | – | 7.46 | 9.14 | 8.34 |
Low-risk | – | 3.44 | – | 3.52 |
Intermediate-risk | – | 6.42 | 6.42 | 6.69 |
High-risk | – | 17.12 | 18.40 | 18.33 |
AFP, alpha fetoprotein; HCC, hepatocellular carcinoma; US, ultrasound.