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. 2024 Aug 13;75:102755. doi: 10.1016/j.eclinm.2024.102755

Table 2.

The mean and 95% credible intervals (brackets) of simulated outcomes.

Outcome Estimate [95% interval]
No surveillance Universal US + AFP surveillance Risk-stratified surveillance Precision surveillance
Lifetime prevalence of HCC 20.8% [20.7%–20.9%] 20.8% [20.6%–20.9%] 20.8% [20.6%–20.9%] 20.7% [20.6%–20.9%]
Total number of surveillance tests per 100,000 population 1,899,075 [1,894,575–1,903,574] 1,404,947 [1,400,556–1,409,337] 1,697,193 [1,692,703–1,701,682]
Number of HCC cases detected per 100,000 population 11,650 [11,480–11,820] 17,387 [17,141–17,633] 16,859 [16,607–17,110] 17,403 [17,158–17,649]
 Mode of detection, %
 Incidental detection 100.0% 18.5% 23.8% 18.7%
 Surveillance detection 0.0% 81.5% 76.2% 81.3%
 Stage at diagnosis, N (%)
 Stage A 4434 (38.0%) 10,972 (63.2%) 10,752 (63.8%) 11,754 (67.6%)
 Stage B 4355 (37.4%) 5573 (32.0%) 5073 (30.0%) 4805 (27.6%)
 Stage C 2699 (23.2%) 772 (4.4%) 953 (5.6%) 773 (4.4%)
 Stage D 161 (1.4%) 70 (0.4%) 80 (0.4%) 71 (0.4%)
 Risk group, N (%)
 Low-risk
 Early stage (stage A) 508 (37.2%) 1319 (63.6%) 508 (37.2%) 1046 (58.6%)
 Late stages (stages B-D) 856 (62.8%) 756 (36.4%) 856 (62.8%) 739 (41.4%)
 Intermediate-risk
 Early stage (stage A) 2203 (38.2%) 5428 (63.2%) 5428 (63.2%) 5885 (67.5%)
 Late stages (stages B-D) 3571 (61.8%) 3157 (36.8%) 3157 (36.8%) 2835 (32.5%)
 High-risk
 Early stage (stage A) 1723 (38.2%) 4225 (62.8%) 4816 (69.7%) 4824 (69.9%)
 Late stages (stages B-D) 2789 (61.8%) 2502 (37.2%) 2094 (30.3%) 2075 (30.1%)
Surveillance efficiency, number of surveillance-detectedcases per 1000 surveillance tests 7.46 9.14 8.34
 Low-risk 3.44 3.52
 Intermediate-risk 6.42 6.42 6.69
 High-risk 17.12 18.40 18.33

AFP, alpha fetoprotein; HCC, hepatocellular carcinoma; US, ultrasound.