Fig. 11.

Irp2^−/− mice are cognitively inflexible

WT and Irp2^−/− completed a reversal learning task using the touchscreen operant platform. A) Both WT and Irp2^−/− mice need more trials to reach criterion levels of performance. B) During reversal, Irp2^−/− mice made many non-correction trial errors. C) Irp2^−/− mice needed as many repeat correction trials just like WT to correct their mistakes. D, E) Non correction trials were grouped into 100 trial bins to generate survival plots for both genotypes. The survival plot for the Irp2^−/− mice were slower to acquire the reversal only. F) During reversal, Irp2^−/− mice make many stimulus-perseverative errors but also many learning errors. *p < 0.05.