Figure 4.

Pharmacokinetics and in vivo hemodynamics. (a) Pharmacokinetics study of SE301 in mice used a single intraperitoneal injection and measured the SE301 serum concentration by ELISA from samples taken before injection and 2, 24, 72, and 168 h postinjection. The serum half-life for SE301 was calculated to be between 77.5 and 130 h. Data are the mean ± s.e.m. and n = 3 for each dose. (b,c) Mouse in vivo hemodynamics study for IV administration of SE301 or Fc N297Q. Heart rate was monitored upon increasing doses of SE301 or Fc N297Q. Plots show either the measured heart rate (b) or the value calculated as a change from the baseline heart rate (c). Data are the mean ± s.e.m. and n = 6, p < 0.0001.