Figure 4.
Fold change per gene per age group relative to adults in fresh intestinal tissue and enteroids, showing maturational patterns in tissue and enteroids. Shown in median ± Min. to Max. (A) P-gp (ABCB1), (B) BCRP (ABCG2), (C) PEPT1 (SLC15A1), (D) MRP2 (ABCC2), (E) CYP3A4, (F) UGT1A1, (G) CYP2C18, and (H) Villin-1. For enteroids, the dots represent the median of the enteroid passages per donor used in the study. (n) is the number of individual donors.