Fig 4.

Activity of DHTs and biguanides against Babesia and Plasmodium species and isolates in vitro. (A-F) In vitro efficacy of dihydrotriazines and biguanides against Babesia [B. duncani WA1 (A), B. divergens Rouen87 (B), and B.MO1 (C)] and Plasmodium species [3D7 (D), Dd2 (E), and HB3 (F)] at 5, 10, 50, and 100 nM drug concentrations. Color-coded heat maps represent mean (n = 3) percent inhibition of parasite growth, with dark blue representing 100% growth and dark red representing 100% inhibition.