TABLE 2.
Definitions of pharmacodynamic model parameters
| Parameter (units) | Definition |
|---|---|
| ipl (total #) | Initial parasite load. Total number of parasites at inoculation or model start |
| µipl (h) | Initial mean parasite age |
| σipl (h) | Standard deviation of the age distribution of the initial parasite load |
| PMF | Parasite multiplication factor. Number of parasites released by a ruptured schizont at the end of the life cycle |
| Emax (% killed/h) | Maximal hourly killing rate of the drug |
| EC50 (ng/mL) | In vivo drug concentration when the killing rate is 50% of Emax |
| γ | Slope of the in vivo drug concentration–effect curve |