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. 2024 Jul 16;39(9):2053–2066. doi: 10.1093/humrep/deae154

Figure 4.

Figure 4.

Metabolic effects of obesity on mouse granulosa cells (GCs). Mitochondrial respiration, glycolysis, fatty acid oxidation (FAO), and ATP production were measured in GCs derived from lean or obese mice at 8-h post-hCG. (A) Mitochondrial function assay; (B) glycolytic function assay; (C) FAO function assay; (D) basal respiration; (E) ATP production inferred from oxygen consumption rate; (F) maximal respiration; (G) proton leak; (H) total ATP production; and (I) ATP production rate from OxPhos versus glycolysis. N = 4 pools of granulosa cells from obese mice and N = 6 pools of cells from obese mice. Data shown as mean ± SEM. Statistical analysis by unpaired two-tailed t-test: ns P > 0.05, *P < 0.05, *int = significant interaction between obesity and OxPhos.